More Good News For Green Tea Lovers: Green Tea Is Effective in Treating Genetic Disorder and Types of Tumors, Study Suggests
We all know that green tea is a powerful anti-oxidant and has many health benefits.
Over the last few decades green tea has been subjected to many scientific and medical studies to determine the extent of its long-purported health benefits, with some evidence suggesting that regular green tea drinkers have lower chances of heart disease and developing certain types of cancer.
Now there is further good news for green tea lovers. Science daily has reported (15 August 2011) on a new study that has come from the Donald Danforth Plant Science Center Philadelphia USA.
A compound found in green tea shows great promise for the development of drugs to treat two types of tumors and a deadly congenital disease. The discovery is the result of research led by principal investigator, Dr. Thomas Smith at The Donald Danforth Plant Science Center and his colleagues at The Children’s Hospital of Philadelphia.
Their findings were recently published in The Journal of Biological Chemistry.
Glutamate dehydrogenase (GDH) is found in all living organisms and is responsible for the digestion of amino acids. In animals, GDH is controlled by a complex network of metabolites. For decades it was not clear why animals required such regulation but other kingdoms did not. This was partially answered by the Stanley group’s finding that a deadly congenital disease, hyperinsulinism/hyperammonemia (HHS), is caused by the loss of some of this regulation. In this disorder, patients (typically children) respond to the consumption of protein by over secreting insulin, becoming severely hypoglycemic, often leading to death.
Using atomic structures to understand the differences between animals and plants, Dr. Smith and his colleagues discovered that two compounds found naturally in green tea are able to compensate for this genetic disorder by turning off GDH in isolated and when the green tea compounds were administered orally. The Smith lab also used X-ray crystallography to determine the atomic structure of these green tea compounds bound to the enzyme. With this atomic information, they hope to be able to modify these natural compounds to design and develop better drugs.
Interestingly, two other research groups have validated and extended these findings to demonstrate that blocking GDH with green tea is very effective at killing two different kinds of tumors; glioblastomas, an aggressive type of brain tumor, and tuberous sclerosis complex disorder, a genetic disease that causes non-malignant tumors to grow on a number of organs.
“While these compounds from green tea are extremely safe and consumed by millions every day, they have a number of properties that make them difficult to use as actual drugs. Nevertheless, our ongoing collaboration with the Stanley lab shows that there are natural compounds from plants that can control this deadly disorder and, with the atomic structure in hand, can be used as a starting point for further drug design.”
Green tea originates from China and has become associated with many cultures in Asia. Europe started importing tea from China in the 17th century. In China, since the Tang dynasty, the very respected Sage of tea Lu Yu said that tea was an elixir from the heavens. In Japan the art of drinking green tea is not only for good health, but is one of the most very important tradition and culture in Japan.
Green tea is tea made with the leaves of Camellia Sinensis that have undergone minimal oxidation.
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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Donald Danforth Plant Science Center.
C. Li, M. Li, P. Chen, S. Narayan, F. M. Matschinsky, M. J. Bennett, C. Stanley, T. J. Smith. Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase In Transgenic Mice By Hijacking The ADP Activation Site.Journal of Biological Chemistry, 2011; DOI:10.1074/jbc.M111.268599